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Join NowIf you’re struggling with eczema, chances are you’ve tried every cream, ointment, and prescription under the sun. But what if the key to clearer skin isn’t something you put on your body, but something that starts in your gut?
Recent research is uncovering a strong, bidirectional link between your digestive system and your skin, particularly when it comes to inflammatory conditions like eczema. Let’s explore how gut health could be the missing piece in your eczema management plan.
The gut skin axis is a communication pathway that connects your digestive system with your skin via the immune, endocrine, and metabolic systems. At the heart of this relationship is the gut microbiome, the trillions of bacteria, fungi, and microbes that live in your intestinal tract. These microbes play a major role in regulating inflammation, immunity, and even your skin barrier function.
When your gut microbiome is in balance, your body can maintain healthy skin by producing beneficial Short Chain Fatty Acids (SCFAs) that calm the immune system. But if it’s imbalanced, a condition known as dysbiosis, you may experience increased systemic inflammation, immune responses, and skin issues like eczema.
In fact, studies show that people with eczema often have reduced levels of beneficial gut bacteria such as Lactobacillus and Bifidobacterium, highlighting a critical imbalance that correlates with disease severity.

The concept of “leaky gut” or intestinal hyperpermeability is central to the gut-skin axis in eczema.
A compromised gut lining, often referred to as leaky gut, occurs when the tight junctions between intestinal cells fail.
This failure allows larger, unwanted particles—such as undigested food particles, toxins, and bacterial byproducts—to escape into the bloodstream (translocation).
The immune system perceives these translocated substances as invaders and mounts a chronic inflammatory response that travels throughout the body, ultimately aggravating existing eczema or contributing to flare ups.
While more research is needed to definitively prove leaky gut causes eczema, studies have found significantly increased intestinal permeability in children with AD, suggesting that improving gut integrity can help reduce systemic inflammation and support long term skin health.
For a scientific overview of how the gut influences inflammatory skin conditions, check out this peer-reviewed article from the NIH.
The good news? There are several natural and evidence backed ways to improve your gut health, which could help manage eczema symptoms from the inside out.
Probiotics are beneficial bacteria that help restore gut balance. Systematic reviews and meta-analyses have shown that specific strains may reduce eczema severity, particularly in adults with severe AD and in infants for prevention.
Prebiotics are a type of non digestible fiber that feed the beneficial bacteria in your gut. They promote an environment where helpful microbes can thrive and produce anti-inflammatory SCFAs.
Sources: Garlic, onions, bananas (unripe), oats, asparagus, whole grains, and chicory root.
A diet rich in colorful vegetables, omega 3 fats (like those found in salmon and flaxseed), and high fiber foods can help reduce systemic inflammation.
Limiting processed foods, refined sugars, and inflammatory additives may also reduce gut irritation and support clearer skin. Focus on a whole food, plant-rich pattern.
Not sure if your gut is contributing to your eczema? These symptoms often occur alongside skin flares, pointing to a need for gut support:
If these sound familiar, consult a physician or registered dietitian about targeted testing for food sensitivities or microbial imbalances.
At Nelladerm, we believe in supporting your skin from the inside and out. While topical treatments like our natural moisturizers and barrier repair formulas are essential, a holistic approach can help address the root causes of inflammation and imbalance.
By nurturing your gut health, you may be able to calm eczema flare ups and restore balance to your skin—naturally.
Healing eczema isn’t always just about what you apply topically—it may also be about what’s happening internally. An imbalanced gut can drive systemic inflammation, disrupt the immune system, and ultimately impact your skin.
Taking steps to support your gut through an anti-inflammatory diet, specific probiotics, and lifestyle changes may help reduce eczema symptoms and improve overall skin health.
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My 7-year old son has been dealing with eczema on his face for a long time, and it’s been so tough to find something that really works…..I’m amazed by the results! Within one day, the redness and rough patches on his face significantly improved…. he doesn’t mind using it at all because it doesn’t sting or feel greasy. – Lily




Like many of you, our eczema journey is personal. That’s why we’re committed to creating a space for the eczema community to share experiences, be empowered through evidence-based solutions, and learn practical tips for daily life.
– Sajjad, Founder & CEO of NellaDerm
